Palazzo Guglielmo Hotel enjoys a central location behind citrus trees and a garden in Vignacastrisi. The 4-star hotel features a swimming pool, a health club and Wi-Fi throughout the property.

Romanelli Cave is nearly a 25-minute walk from the property, while Vaste is around 10 minutes' drive away. The hotel offers proximity to natural sights like Cala dell'Acquaviva Beach (3.2 km) and Porto Miggiano Beach (3.3 km). The accommodation is also approximately 10 minutes by car from Grotta Zinzulusa Cave. The nearest airport is Casale airport, 90 km from Palazzo Guglielmo Hotel.

The property has 15 rooms, some of them comprise a patio and a balcony, and have self-catering options such as tea and coffee making facilities. For your comfort, you will find a Jacuzzi bath, a separate toilet, and a shower, along with hairdryers and towels. Guests can take advantage of views of the garden.

The Palazzo Guglielmo Vignacastrisi offers a fine cold buffet breakfast in the restaurant. The poolside bar on-site has its own Wi-Fi and a TV. The dessert restaurant Al Portio is located only 550 metres away.